Estracon Vaginal Cream (Conjugated estrogen 0.625mg/gm) contains Estrogen hormones derived from ovaries and is used to alleviate menopausal symptoms like vaginal atrophy, hot flashes, vaginal dryness, and itching.
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Conjugated Estrogen is a type of hormone replacement therapy used to address menopause-related symptoms and conditions. Menopause brings decreased estrogen levels, leading to issues like hot flashes and a risk of osteoporosis. These estrogens can replace the hormone, help regulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and improve menopausal symptoms.
Follow your doctor's guidance on dosing and duration. Possible side effects encompass vaginal bleeding, breast pain/swelling, nausea, abdominal discomfort, headaches, mood changes, joint pain, and more.
Avoid Conjugated Estrogen if you've had breast/uterine cancer, unexplained vaginal bleeding, blood clot history, heart issues, liver disease, or if pregnant/breastfeeding. Cease usage and seek medical attention for reactions like jaundice, high blood pressure, migraines, pregnancy, blood clot signs, or sugar intolerance.
Consumption of alcohol while using this medicine may cause interactions.
Use of Estracon Vaginal Cream is not recommended if you are pregnant or planning a pregnancy in the immediate future. Contact your doctor if you suspect a pregnancy while being treated with this medicine.
Estracon Vaginal Cream is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
Estracon Vaginal Cream may not affect your ability to drive.
Estracon Vaginal Cream should be used with caution in patients with severe kidney diseases. Hence If you have a pre-existing or a history of kidney disease, inform your doctor before taking Estracon Vaginal Cream. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.
Estracon Vaginal Cream should not be used in patients with liver diseases. Hence inform your doctor if you have/had a history of liver disease before starting treatment with this medicine.
Conjugated Estrogen contains the hormone 'conjugated estrogens,' used in hormone replacement therapy (HRT) to counter low estrogen levels during menopause. It replaces this hormone and regulates pituitary gland secretions like luteinizing hormone (LH) and follicle-stimulating hormone (FSH), critical for sexual function and the menstrual cycle. These actions alleviate menopausal symptoms.
Estracon 15gm Vaginal Cream is indicated in the following indications-
Endogenous estrogens play a crucial role in shaping the female reproductive system and secondary sexual characteristics. While estrogen levels continually shift through metabolic processes, the most influential intracellular estrogen is estradiol, which surpasses estrone and estriol in receptor potency. In menstruating women, the primary source of estrogen—generating 70 to 500 mcg of estradiol daily—stems from the ovarian follicle, with production varying based on the menstrual phase.
Following menopause, endogenous estrogen primarily arises from the peripheral tissue conversion of adrenal cortex-secreted androstenedione into estrone. This results in the abundance of estrone and its sulfate-conjugated form, estrone sulfate, in postmenopausal women.
Estrogens function by binding to nuclear receptors within estrogen-responsive tissues, with two types of estrogen receptors recognized, their presence varying among tissues. Circulating estrogens regulate the secretion of pituitary gonadotropins—luteinizing hormone (LH) and follicle-stimulating hormone (FSH)—via negative feedback. In postmenopausal women, estrogens act to reduce elevated gonadotropin levels.
For the treatment of atrophic vaginitis and kraurosis vulvae, the administration of Conjugated Estrogens involves the following steps:
Dosage and Regimen: Start with a 0.5 gm dosage strength. Administer intravaginally using a cyclic regimen of 21 days of daily use followed by 7 days off.
Dosage Adjustment: Depending on individual response, the dosage can be adjusted within the range of 0.5 to 2 gm.
For moderate to severe dyspareunia (painful intercourse) due to vulvar and vaginal atrophy:
Dosage: Use 0.5 gm intravaginally.
Frequency: Apply twice weekly, for example, on Mondays and Thursdays. This can be done either in a continuous regimen or in a cyclic regimen of 21 days of daily administration followed by 7 days off.
Here's how to administer the medication using an applicator:
To clean the applicator:
It's essential to follow the prescribed dosage, regimen, and administration instructions provided by your healthcare provider. If you have any doubts or concerns, always consult your doctor or healthcare professional for clarification.
Conjugated Estrogen can interact with various medications:
Avoid grapefruit/grapefruit juice while on Conjugated Estrogen to reduce side effect risk.
Conjugated Estrogen should not be used in conditions such as breast/endometrial cancer, unexplained vaginal bleeding, untreated endometrial hyperplasia, blood clot history, heart issues, inherited porphyria, or liver disease.
Conjugated Estrogen use is contraindicated in the following situations:
It's important to adhere to these contraindications and consult a healthcare professional before starting or discontinuing any medication.
If pregnancy occurs while undergoing treatment with Conjugated estrogen, the medication should be stopped promptly. The existing epidemiological studies suggest that accidental fetal exposure to estrogens is not associated with teratogenic (malformation-inducing) or fetotoxic (harmful to the fetus) effects. However, it's still crucial to consult a healthcare professional in such situations to ensure appropriate management and advice regarding the continuation of treatment or any potential risks to the pregnancy.
Before starting treatment with Conjugated Estrogen, it's crucial to inform your doctor if you're allergic to it or have conditions like fibroids, endometriosis, thickened womb lining, blood clot risk, family history of estrogen-sensitive cancer, high blood pressure, liver/kidney/heart diseases, fluid retention, diabetes, gallbladder stones, migraines, lupus, epilepsy, asthma, osteosclerosis, low blood calcium, or high blood fat levels.
Conjugated Estrogen raises the risk of endometrial hyperplasia and cancer, prompting the potential prescription of 'progesterone' to counter this. If pregnant or breastfeeding, avoid using Conjugated Estrogen, as it's not recommended. Prolonged high-dosage usage may heighten risks of heart attack, stroke, clots, dementia, and breast/uterine cancer. Consult your doctor, especially if you still have a uterus, to discuss progestin use.
Store in a cool (below 30°C) and dry place, protected from light and moisture.
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